• Subcutaneous administration of antibiotics is a common practice in France, despite the absence of marketing authorization and a lack of formal recommendations.
• The SC route provides a pragmatic solution in numerous situations where oral, intravenous, or intramuscular routes are contraindicated or considered too invasive or uncomfortable.
• A substantial body of high-quality scientific evidence has been published in recent years, through which this practice has been more precisely described.
• The relevant data are summarized in this article, and guidelines are issued on behalf of the SPILF and the SFGG to define the indications, modalities of use, and regulatory framework for subcutaneous antibiotic therapy.

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